Research Related Articles

Research related articles

Copper Oxide Nanoparticles: Synthesis, Characterization and Their Antibacterial Activity

Sunita Jadhav, Suresh Gaikwad,Madhav Nimse, Anjali Rajbhoj

Abstract - Copper oxide nanoparticles were prepared by electrochemical reduction method using tetra butyl ammonium bromide (TBAB) as structure directing agent in an organic medium viz. tetra hydro furan (THF) and acetonitrile (ACN) in 4:1 ratio by optimizing current density and molar concentration of the ligand. The reduction process takes place under inert atmosphere of nitrogen over a period of 2 h. Such nanoparticles are prepared using simple electrolysis cell in which the sacrificial anode as a commercially available copper metal sheet and platinum (inert) sheet act as a cathode. The parameters such as current density, solvent polarity, distance between electrodes, and concentration of stabilizers are used to control the size of nanoparticles. The synthesized copper oxide nanoparticles were characterized by using UV–Visible, FT-IR, XRD, SEM–EDS and TEM analysis techniques. The nanoparticles were tested for antibacterial activity against human pathogens like Escherichia coli (E. coli) and Staphylococcus strains and which was proved to be excellent.

Physico-chemical and Biological Analysis of N-4-Disbstituted Thiosemicarbazone Ligand and its Transition Metal Complexes

Gavhane V.S., Suryawanshi D.M., Rajbhoj A.S. and Gaikwad S.T*

Abstract - The Cr(III), Mn(II), Fe(II) and Ni(II) transition metal complexes of novel (E)-1-(2-hydroxybenzylidene)-4,4diethylthiosemicarbazide have been prepared and characterized by micro analysis (elemental), spectral (FTIR, 1H-NMR),molar conductivity and X-ray diffraction studies. A molar conductivity measurement shows that, Cr (III) and Fe (II) complex of ligand (HBDT) are electrolytic in nature. FTIR studies suggested the attachment of central metal ion to ligand portion through the imine linkage-nitrogen, thioketonic sulphur and phenolic oxygen. According to spectral studies an octahedral geometry may be assigned for all four complexes. The ligand (HBDT) and its transition metal complexes have also been tested for their antibacterial and antifungal activity against Staphylococcus aureus, Bacillus substilis, Aspergillus niger and Fusarium oxysporum species. All complexes and ligand showed considerable activity compared with standard drug ciprofloxacin.

Preparation, characterization and catalytic activity of MoO3/CeO2–ZrO2 solid heterogeneous catalyst for the synthesis of b-enaminones

Sandip B. Rathod, Machhindra K. Lande *, Balasaheb R. Arbad, Anil B. Gambhire

Abstract - A series of CeO2–ZrO2 with different molybdenum (8–20 wt% MoO3) loaded materials were prepared by homogeneous co-precipitation followed by impregnation method. The prepared materials were tested for their catalytic activity performance in the synthesis of b-enaminones by condensation of various anilines with dimedone under solvent-free conditions in microwave providing excellent yields within short reaction time. An obtained result reveals that, catalytic activity increases with increase in Mo wt% loading. The particle size of prepared materials was estimated using Debye–Scherrer equation. 

Synthesis, spectral, thermal and antimicrobial studies of transition metalcomplexes of 14-membered tetraaza[N4] macrocyclic ligand

Sunil G. Shankarwar, Bhagwat B. Nagolkar, Vinod A. Shelke, Trimbak K. Chondhekar

Abstract - A series of metal complexes of Mn(II), Co(II), Ni(II), Cu(II), have been synthesized with newly synthesized biologically active macrocyclic ligand. The ligand was synthesized by condensation of b-diketone 1-(4-chlorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione and o-phenylene diamine. All the complexeswere characterized by elemental analysis, molar conductivity, magnetic susceptibility, thermal analysis,X-ray diffraction, IR, 1H-NMR, UV–Vis spectroscopy and mass spectroscopy. From the analytical data,stoichiometry of the complexes was found to be 1:2 (metal:ligand). Thermal behavior (TG/DTA) andkinetic parameters suggest more ordered activated state in complex formation. All the complexes areof high spin type and six coordinated. On the basis of IR, electronic spectral studies and magnetic behavior,an octahedral geometry has been assigned to these complexes. The antibacterial and antifungalactivities of the ligand and its metal complexes, has been screened in vitro against Staphylococcus aureus,Escherichia coli and Aspergillus niger, Trichoderma respectively.

Ultrasonic promoted catalyst-free N-formylation of amines in neutral ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate

Vinod T. Kamble,Giribala M. Bondle,Parshuram M. Pisal.

Abstract - A catalyst-free, simple and efficient protocol for N-formylation of alkyl, aryl, and heteroaryl amines with formic acid under ultrasonic irradiation at room temperature using 1-butyl-3-methylimidazolium tetrafluoroborate [Bmim]BF4 as a neutral medium is described.

Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation

Dnyaneshwar D. Subhedar,Mubarak H. Shaikh,Bapurao B. Shingate,Laxman Nawale,Dhiman Sarkar,Vijay M. Khedkar,Firoz A. Kalam Khan,Jaiprakash N. Sangshetti

Abstract -  A series of rhodanine incorporated quinoline derivatives were efficiently synthesized using reusable DBU acetate as ionic liquid and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Ra (MTB) (ATCC 25177) and Mycobacterium bovis BCG (ATCC 35743) both in active and dormant state. Compounds 3e, 3f, 3g, 3h and 3i exhibited very good antitubercular activity. The active compounds were studied for cytotoxicity against HUVEC, THP-1, macrophages, A549, PANC-1 and HeLa cell lines using modified MTT assay and were found to be noncytotoxic. Inactivity of all these compounds against Gram positive and Gram negative bacteria indicates their specificity towards the MTB. Further, the synthesized compounds have been screened for their in vitro antifungal activity. In addition, the molecular docking studies revealed the binding modes of these compounds in active site of Zmp1 enzyme, which in turn helped to establish a structural basis of inhibition of mycobacteria.

Silver nanoparticles sensitized C 60 (Ag@ C 60) as efficient electrocatalysts for hydrazine oxidation: Implication for hydrogen generation reaction (Applied Surface Science; 2016)

Shankar S. Narwade, Balaji B. Mulik, Shivsharan M. Mali, Bhaskar R. Sathe*

Abstract - Fullerene (C60; 15 ±2 nm) sensitized with silver nanoparticles (Ag NPs; 10 ± 0.5 nm) (Ag@C60) as efficient electrocatalyst is reported for the oxidation of hydrazine, which demonstrates activity close to that of Pt in acidic, neutral and basic media. The performance is comparable with the best available electrocatalytic system and plays a vital role in the overall hydrogen generation reactions from hydrazine.